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MS 15203

CAS No. 73912-52-4

MS 15203( —— )

Catalog No. M34916 CAS No. 73912-52-4

MS 15203 is a selective GPR171 agonist that increases morphine antinociception and is effective in reducing chronic pain. It can reduce chronic neuropathic and inflammatory pain in male mice.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    MS 15203
  • Note
    Research use only, not for human use.
  • Brief Description
    MS 15203 is a selective GPR171 agonist that increases morphine antinociception and is effective in reducing chronic pain. It can reduce chronic neuropathic and inflammatory pain in male mice.
  • Description
    MS15203 is a potent and selective GPR171 agonist. MS15203 increases food intake and body weight. MS15203 increases neuronal activity. MS15203 significantly increases the abundance of the mRNAs encoding proSAAS, NPY, AgRP.
  • In Vitro
    MS15203 (MS0015203) dose-dependently increases [[35]S]GTPγS binding and inhibits adenylyl cyclase activity in rat hypothalamic membranes.
  • In Vivo
    MS15203 (MS0015203) (3 mg/kg; i.p.) causes an increase in neuronal activity within cells containing GPR171 in the PVN..MS15203 (3 mg/kg; i.p.) significantly increases food intake at 4 and 8 hours.MS15203 (3 mg/kg; i.p.) significantly increases the abundance of the mRNAs encoding proSAAS, NPY, AgRP.
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    GPR
  • Recptor
    GPR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    73912-52-4
  • Formula Weight
    249.22
  • Molecular Formula
    C12H11NO5
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 50 mg/mL (200.63 mM; Ultrasonic (<60°C)
  • SMILES
    O=C(O)C1=CC(=CC(=C1)C(=O)O)NC(=O)C(=C)C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Wardman JH, et al. Identification of a small-molecule ligand that activates the neuropeptide receptor GPR171 and increases food intake. Sci Signal. 2016 May 31;9(430):ra55. ?
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